Charm II Beta-lactams

Charm offers multiple Charm II Beta-lactam Tests for milk, tissue and other food products. Many of the Charm II Beta-lactam Tests for Milk are US FDA-approved screening tests that have been accepted under the requirements of Appendix N of the Grade “A” Pasteurized Milk Ordinance (PMO). Charm II Beta-lactam Tests are designed for use by laboratory and regulatory personnel.

Charm II Beta-lactam Tests use a binding reagent with specific receptor sites that bind beta-lactam drugs. The binder is added to a sample along with an exempt amount of labeled penicillin (tracer). Any beta-lactam drugs in the sample compete for the binding sites with this tracer. The amount of tracer that binds to the receptor sites is measured and compared to a previously determined Control Point. The Control Point is the cutoff point between a negative or positive sample. The greater the amount of tracer measured, the lower the beta-lactam concentration in the sample. The smaller the amount of tracer measured, the greater the beta-lactam concentration in the sample.

Charm II tests run on the Charm II system and are designed for use by veterinarians, laboratory and regulatory personnel. They provide a comprehensive analysis of biological residues on multiple matrices, and meet EU MRLs and US FDA Safe Levels.

Charm II tests use a binding reagent with specific receptor sites. The binder is added to a sample along with an exempt amount of labeled tracer. Any drugs in the sample compete for the binding sites with this tracer. The amount of tracer that binds to the receptor sites is measured and compared to a previously determined Control Point. The Control Point is the cutoff point between a negative or positive sample. The greater the amount of tracer measured, the lower the drug concentration in the sample. The smaller the amount of tracer measured, the greater the drug concentration in the sample.

Benefits

  • Milk tests detect beta-lactams to US or EU/CODEX levels. If needed, test for cloxacillin separately at lower (8.5 ppb) sensitivity.
  • The US milk assays are recognized by the NCIMS (National Conference on Interstate Milk Shipments)
  • Tissue and fish tests detect beta-lactams at or below US safe levels Test grains for 22 beta-lactam drugs
  • Test eggs for penicillin
  • Test honey
  • Tests take 10 t0 15 minutes after any needed extraction
  • One platform tests multiple sample types
  • Tests designed for use by veterinary, laboratory, field, and regulatory personnel

Regulatory Info

  • Detects five beta-lactam drugs and flunixin at or below US safe levels.
  • The TBL8test is recognized by the National Conference on Interstate Milk Shipments (NCIMS).
  • The Charm II beta-lactam milk test, TBL8MRL, detects 16 beta-lactam drugs at or below EU MRL.
  • Central Reference Laboratory (CRL) guidelines available upon request.

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